Heartworm disease is one of the most serious health threats for cats, yet many pet parents underestimate its risk. While dogs are the primary host, cats can also be infected by heartworms carried through mosquito bites. Even a small number of worms can lead to severe lung damage, heart complications, or sudden death in cats. The good news is that prevention is not only possible but also highly effective.
In 2025, veterinarians continue to recommend trusted, safe, and effective medications to protect cats from heartworms, fleas, ticks, and other parasites. Below, we highlight the best heartworm prevention products for cats, including well-known options like NexGard Combo, Advantage Multi, Revolution Plus, Stronghold Plus, Revolution, and Stronghold. These products are vet-approved and designed to keep your feline companion safe and healthy all year round.
Why Heartworm Prevention Matters for Cats
Unlike dogs, cats are not the ideal hosts for heartworms, but that does not make them safe. A single mosquito bite can introduce heartworm larvae, which migrate to the lungs and heart. Even one or two worms can trigger a dangerous condition known as heartworm-associated respiratory disease (HARD).
Symptoms may include:
- Coughing or wheezing
- Vomiting
- Loss of appetite
- Sudden collapse or even death in severe cases
Unfortunately, there is no approved treatment for heartworm in cats. This makes prevention the only reliable way to protect your pet.
The Best Heartworm Preventatives for Cats in 2025
Here are the most effective and recommended products by veterinarians today:
1. NexGard Combo for Cats
NexGard Combo is one of the newest and most advanced all-in-one preventatives for cats. It protects against:
This topical solution is easy to apply and provides broad-spectrum protection, making it a convenient choice for cat owners who want a single monthly treatment.
2. Advantage Multi (Also known as Advocate in some regions)
Advantage Multi is a trusted topical solution that protects against:
Vets widely recommend it because of its proven safety record and effectiveness. A monthly dose ensures your cat is covered from multiple parasites without the need for various products.
3. Revolution Plus for Cats
Revolution Plus has become one of the most popular preventatives for cats in recent years. It protects against:
- Heartworms
- Fleas and ticks
- Ear mites
- Roundworms and hookworms
This six-in-one topical solution is particularly beneficial for outdoor cats or those living in areas with a high risk of flea and tick infestations.
4. Stronghold Plus
Stronghold Plus is very similar to Revolution Plus, offering wide protection against:
- Heartworm disease
- Fleas and ticks
- Ear mites
- Roundworms and hookworms
It is safe for cats as young as eight weeks old, making it an excellent choice for kittens once they reach the appropriate age.
5. Revolution (Original Formula)
For cats that may not require tick protection, the classic Revolution remains an excellent option. It covers:
- Heartworms
- Fleas
- Ear mites
- Roundworms and hookworms
This is a reliable monthly preventive for indoor cats who may have limited exposure to ticks but still face risks from heartworm and fleas.
6. Stronghold (Original Formula)
Like Revolution, Stronghold is the standard version that protects against:
- Heartworms
- Fleas
- Ear mites
- Intestinal worms
It has a long history of safe use in cats and is still recommended by veterinarians worldwide.
7. Bravecto Plus for Cats (Additional Option)
While not included in every vet’s first-line recommendation, Bravecto Plus is worth mentioning. It protects against:
- Heartworms
- Fleas and ticks
- Roundworms and hookworms
What makes Bravecto Plus unique is its extended duration of protection. Instead of monthly applications, it lasts up to 12 weeks, reducing the number of treatments needed each year.
How to Choose the Right Product for Your Cat
When selecting the best heartworm preventive for your cat, consider the following factors:
- Lifestyle: Outdoor cats or those in multi-pet households may benefit from broad-spectrum protection (fleas, ticks, worms). Indoor cats still need heartworm protection since mosquitoes can enter your home.
- Geographic Location: If you live in warmer states, your cat faces a year-round risk of exposure to mosquitoes and fleas.
- Veterinary Recommendation: Your veterinarian can provide guidance based on your cat’s age, health condition, and risk factors.
- Ease of Application: Most products are topical, but duration and coverage vary (monthly vs. quarterly).
Tips for Effective Heartworm Prevention
- Stay consistent: Apply preventives on schedule, as missing even one dose can leave your cat unprotected.
- Pair with regular checkups: Annual vet visits and heartworm testing help ensure your cat remains parasite-free.
- Avoid dog-only products: Never use preventatives meant for dogs, as they may contain ingredients toxic to cats.
Final Thoughts
Heartworm disease in cats is dangerous and untreatable once infection occurs. Prevention is the only way to safeguard your feline friend. With options like NexGard Combo, Advantage Multi, Revolution Plus, Stronghold Plus, Revolution, Stronghold, and Bravecto Plus, pet parents have multiple safe and effective choices in 2025.
Protecting your cat from heartworms, fleas, ticks, and intestinal parasites ensures a longer, healthier, and happier life. Consult with your veterinarian to select the product that best suits your cat’s needs and lifestyle.
