Heartworm disease is one of the most serious health risks dogs face today. Transmitted by mosquitoes, this condition can lead to severe heart failure, lung damage, and even death if left untreated. Fortunately, veterinarians recommend a variety of safe and effective preventive medications that keep your furry friend protected year-round.
In 2025, dog owners will have more choices than ever, ranging from chewable tablets to topical solutions that not only prevent heartworms but also protect against other parasites, such as fleas, ticks, and intestinal worms. Below, we’ve rounded up the 7 best heartworm preventive products for dogs, all highly recommended by veterinarians.
1. Interceptor® Plus Chew for Dogs
Best Broad-Spectrum Protection
Interceptor Plus is a monthly flavored chew that protects dogs against heartworms, as well as common intestinal parasites, including roundworms, hookworms, whipworms, and tapeworms. It’s easy to administer and comes in a palatable chew that most dogs enjoy.
Why vets recommend it:
- Covers five major parasites in one dose.
- Simple once-a-month routine.
- Ideal for families seeking all-around protection.
2. Advantage Multi® Topical Solution for Dogs
Best for Dogs Who Dislike Chewables
Some dogs refuse to take chewable tablets. For them, Advantage Multi is a great solution. This topical medication, applied to the back of your dog’s neck, prevents heartworms and treats flea infestations, sarcoptic mange, and intestinal worms.
Why vets recommend it:
- Convenient topical application.
- Protects against both internal and external parasites.
- Great option for picky eaters.
3. Heartgard® Plus Chew for Dogs
Most Popular Choice Among Pet Owners
Heartgard Plus is one of the most trusted names in heartworm prevention. This beef-flavored chew is highly palatable and protects against heartworms, roundworms, and hookworms.
Why vets recommend it:
- Long-standing reputation for safety and effectiveness.
- Dogs love the taste, making it easy to give.
- Widely available and affordable.
4. Iverhart Max® Chew for Dogs
Best Value Option
Iverhart Max offers broad-spectrum protection in a chewable form, covering heartworms, roundworms, hookworms, and tapeworms. It is often more budget-friendly compared to other options without compromising on quality.
Why vets recommend it:
- Effective multi-parasite coverage.
- More economical for households with multiple pets.
- Comes in flavored chews for easy administration.
5. Simparica Trio® Chewable Tablet for Dogs
Best All-in-One Protection
Simparica Trio is a comprehensive chewable tablet that protects against heartworms, fleas, ticks, roundworms, and hookworms—all in one monthly dose. It’s especially convenient for pet parents who want complete parasite protection with a single product.
Why vets recommend it:
- Covers both internal and external parasites.
- Helps prevent Lyme disease by controlling ticks.
- Once-a-month convenience.
6. NexGard® PLUS Chewables for Dogs
Best All-in-One (Runner-Up)
NexGard PLUS is a newer option that combines flea, tick, and heartworm protection in a delicious beef-flavored chew. It also protects against roundworms and hookworms, making it another strong all-in-one choice.
Why vets recommend it:
- Effective against fleas, ticks, and intestinal worms.
- Safe and easy to give monthly.
- Strong contender alongside Simparica Trio.
7. Revolution® Topical Solution for Kittens & Puppies
Best for Puppies
For younger dogs, especially puppies under six weeks old, Revolution is a gentle yet powerful option. This topical solution prevents heartworms while also treating fleas, ear mites, and sarcoptic mange. It’s safe for puppies as young as six weeks, making it an excellent starter preventive.
Why vets recommend it:
- Puppy-safe formula.
- Protects against multiple parasites.
- Easy topical application.
How to Choose the Right Heartworm Preventive for Your Dog
Keep these key points in mind when choosing the best product for your dog:
- Your dog’s age and weight: Some medications are only suitable for dogs above a certain age or within a specific weight range.
- Your dog’s daily routine: Pets that spend a lot of time outside often benefit from comprehensive protection that covers not only heartworms but also fleas and ticks.
- Ease of administration: If your dog dislikes chewables, a topical solution like Advantage Multi or Revolution may be the best option.
- Budget: Options like Iverhart Max provide adequate protection at a more affordable price.
- Veterinarian’s advice: Always consult your vet before starting any heartworm preventive. A simple blood test is often required to ensure your dog is free from heartworms before beginning treatment.
Why Heartworm Prevention Is Non-Negotiable
Heartworm treatment is not only costly but also dangerous for dogs. Preventive medications, on the other hand, are safe, effective, and affordable. Year-round prevention ensures your pet is fully protected, even during cooler months when mosquitoes may still be active.
Final Thoughts
Heartworm prevention should be a top priority for every dog owner. Whether you prefer a chewable like Heartgard Plus or Simparica Trio, or a topical solution like Advantage Multi, there’s a safe and effective option for every pet. Maintaining a consistent heartworm prevention routine helps safeguard your dog’s health, keeping them protected and ensuring they enjoy a longer, happier life by your side.
If you’re unsure which product is right for your dog, speak with your veterinarian—they can recommend the best solution tailored to your dog’s health needs and lifestyle.
