Heartgard Plus vs. Trifexis

Comparison between Heartgard Plus and Trifexis

Once your dog has heartworm disease, it can be costly and difficult to remove. However, several treatments are available on the market, and you can keep your dog safe with monthly oral treatment.

Heartgard Plus and Trifexis protect your dog from developing heartworm and prevent roundworms and hookworms. However, Trifexis has the advantage of treating flea infections by killing eggs, larvae, and adult fleas and protecting against whipworms.

Heartgard Plus is safe for puppies and dogs from the age of six weeks, and no minimum weight is required. In addition, these products are safe for nursing and pregnant dogs. Trifexis is safe for puppies and dogs at the age of eight weeks and has a minimum weight of 5 lbs (2.3 kg).

You should first consider whether these products suit your dog’s needs. Trifexis is not safe for breeding males and should be used with caution on pregnant females. Heartgard Plus is safe to use on breeding and pregnant dogs.

If the pet gets heartworm, it can be tough to treat, so prevention is better than cure. Here is our comparison of the leading brand of heartworm preventatives.

Heartgard Plus For Dogs
Trifexis For Dogs
Kills Fleas
Repels Fleas
Kills Flea Eggs and Larvae
Prevents Heartworm
Prevents Roundworms
Prevents Hookworms
Prevents Whipworms
Other Parasites
Safe for Pregnant or Nursing Pets
When does it starts working
Begins working Immediately
Kills fleas within 30 minutes; kills 100% of fleas within 4 hours
Beef-flavored chewable
Beef-flavored tablet
Active Ingredient(s)
Ivermectin, Pyrantel Pamoate



Shop by Category