Common Brand Names

Single Ingredient

  • Comfortis for Dogs and Cats

Combined Ingredients

Uses Of Spinosad

Spinosad is an acaricide and insecticide used to control external parasites in cats and dogs.

Spinosad also kills adult fleas in cats and dogs and is indicated for treating and preventing flea infections.

Method Of Application

Spinosad comes as an oral application supplied as a chewable.

Dosage And Administration

The specific dosage and administration of spinosad-containing pet medications will vary depending on the product and the pet for which it is intended. Therefore, it is important to carefully read and follow the instructions on the product label or as directed by a veterinarian.

For example, Comfortis is a spinosad-based oral medication for dogs and cats that is available in different strengths for different weight ranges of pets. The recommended dosage for dogs is based on their weight, and the tablets are given once a month.

Trifexis is a chewable tablet given orally to dogs once a month and contains spinosad and milbemycin oxime. It is used to prevent heartworm disease, kill fleas and treat and control adult hookworm, roundworm, and whipworm infections.

It is crucial to consult with a veterinarian to determine the correct dosage and administration for your pet. It is also important to use the product only for the animal it is intended for and not for other species.

Possible Side Effects

Like with any medication, spinosad-containing products can cause side effects in some pets. The most common side effects are mild and short-lived, such as vomiting, diarrhea, loss of appetite, and lethargy. These side effects usually resolve on their own within a day or two and do not require treatment.

In rare cases, pets may experience more severe side effects, such as an allergic reaction, seizures, or depression. If you notice any of these symptoms, contact your veterinarian immediately.

It is important to note that not all pets will experience side effects, and for most pets, spinosad is considered safe and well-tolerated. However, it is also important to use the product only for the animal for which it is intended and to follow the instructions on the label or as directed by a veterinarian.

As always, it is important to consult a veterinarian before administering any medication to your pet. They can advise you on the most appropriate treatment plan for your pet and monitor your pet for any potential side effects.


When using spinosad-containing products, certain precautions should be taken to ensure the safety and well-being of your pet.

  • Always read and follow the instructions on the product label or as directed by a veterinarian.
  • Use the product only for the animal for which it is intended. Please do not use it on other species.
  • Use the appropriate dosage for your pet's weight and species. Overdosing can lead to serious side effects.
  • Consult a veterinarian before administering the medication if your pet is pregnant, nursing, or has any pre-existing medical conditions.
  • Keep the medication out of reach of children and other pets.
  • Monitor your pet for any signs of side effects and contact your veterinarian immediately if you notice anything unusual.
  • Spinosad may interact with other medications your pet is taking, so be sure to inform your veterinarian of all medicines, vitamins, and supplements your pet is currently taking.

Following these precautions ensures that your pet receives the appropriate treatment and minimizes the risk of any adverse reactions.

Signs Of Toxicity

Signs of toxicity can occur when an animal is exposed to high levels of spinosad or when they are sensitive to the medication. In general, signs of toxicity are related to the nervous system and may include the following:

  • Excitement or agitation
  • Tremors or muscle twitching
  • Seizures
  • Loss of coordination
  • Depression or lethargy
  • Loss of appetite
  • Vomiting or diarrhea
  • Rapid breathing
  • In severe cases, coma or death

Suppose you suspect your pet has been exposed to a toxic level of spinosad or has an adverse reaction to the medication. In that case, it is important to contact your veterinarian immediately. They will be able to assess the severity of the situation and provide appropriate treatment. In case of overdose, treatment may include using activated charcoal, symptomatic treatment, and supportive care.

It is important to remember that toxicity is rare. Always consult a veterinarian if you notice any signs of toxicity in your pet, and follow the instructions on the product label or as directed by a veterinarian.


Protect from light. Store between 68-77°F (20-25°C).


The information provided on this page is for normal reference only and is not intended to replace veterinary advice or packaging label. You should consult your vet first. Here may have included only some of the uses, side effects, brand names, or applications.

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