Simparica Trio For Dogs
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Simparica Trio for Dogs – Complete Monthly Protection Against Fleas, Ticks & Worms
Simparica Trio is a broad-spectrum, monthly chewable treatment designed to protect dogs against fleas, ticks, heartworms, and intestinal worms. It combines three powerful active ingredients—sarolaner, moxidectin, and pyrantel—to deliver comprehensive parasite protection in a single dose.

How Simparica Trio Works
Simparica Trio works through a combination of three active ingredients:
-
Sarolaner: Targets and kills fleas and ticks by overstimulating their nervous system, leading to rapid elimination. It is effective against multiple tick species, including:
- Deer tick (black-legged tick)
- American dog tick
- Lone Star tick
- Brown dog tick
- Gulf Coast tick
- Pyrantel: A deworming agent that treats and controls roundworms and hookworms in dogs.
- Moxidectin: Prevents heartworm disease by eliminating immature heartworm larvae and also helps control lungworms.

Key Benefits of Simparica Trio
- Monthly all-in-one chewable tablet.
- Kills fleas quickly and protects against re-infestation.
- Effective against 5 species of ticks.
- Prevents heartworm disease.
- Treats and controls roundworms and hookworms.
- Helps protect against lungworms.
- Tasty liver-flavored chew for easy administration.
Who Can Use Simparica Trio?
Simparica Trio is suitable for:
- Suitable for dogs and puppies 8 weeks of age and older.
- Dogs weighing at least 2.8 lbs (1.2 kg).
⚠️ Important:
- Ensure your dog is tested for heartworm infection before starting treatment.
- Not recommended for pregnant or lactating dogs unless advised by a veterinarian.
How to Use Simparica Trio
- Administer one chewable tablet once a month.
- Can be given with or without food.
- If a dose is missed, give it as soon as you remember, then continue monthly.
For best protection:
- Use year-round, especially in areas with fleas and mosquitoes.
- Ensure all dogs in the household are treated to help prevent reinfestation.
Precautions
- Wash your hands after handling the tablet.
- Store in original packaging until use.
- Keep out of reach of children and pets.
- Use only as directed by your veterinarian.
Possible Side Effects
Simparica Trio is generally well tolerated. However, in rare cases, dogs may experience:
- Vomiting
- Diarrhea
- Lethargy
- Loss of appetite
- Increased urination
- Hyperactivity
If symptoms persist, consult your veterinarian.
Dosage Chart
|
Pack Color |
Body Weight |
Dog Size |
Sarolaner per tablet (mg) |
Moxidectin per Tablet (mg) |
Pyrantel per tablet (mg) |
Number of administered tablets |
Product Page |
|
Gold |
2.8 - 5.5 lbs (1.25 - 2.5 kg) |
Puppy |
3 |
0.06 |
12.5 |
One |
|
|
Purple |
5.6 - 11 lbs (2.5 - 5 kg) |
X-Small |
6 |
0.12 |
25 |
One |
|
|
Caramel |
11.1 - 22 lbs (5 - 10 kg) |
Small |
12 |
0.24 |
50 |
One |
|
|
Teal |
22.1 - 44 lbs (10 - 20 kg) |
Medium |
24 |
0.48 |
100 |
One |
|
|
Green |
44.1 -88 lbs (20 - 40 kg) |
Large |
48 |
0.96 |
200 |
One |
|
|
Brown |
88.1 - 132 lbs (40 - 60 kg) |
X-Large |
72 |
1.44 |
300 |
One |
Frequently Asked Questions
Is Simparica Trio safe for small dogs?
Yes, it is safe for dogs weighing at least 2.8 lbs and 8 weeks old.
How often should I give Simparica Trio?
It should be given once every month.
How fast does it work?
- Starts killing fleas within 4 hours
- Kills ticks within 8 hours
Can I use Simparica Trio for cats?
No, this product is only for dogs.
Can I split the tablet?
No, tablets should be given whole for accurate dosing.
What if my dog vomits after taking it?
If the full dose is not retained, consult your vet about re-dosing.