Heartgard Plus vs. Revolution for Dogs: Which One Should You Choose?

Two names often stand out when it comes to protecting your dog from harmful parasites like heartworms, fleas, and intestinal worms: Heartgard Plus and Revolution. Veterinarians and pet owners trust them, but they serve slightly different purposes. Selecting the best product for your dog relies on factors like your dog’s daily routine, specific health requirements, and the climate in your area.

This article explores Heartgard Plus and Revolution by examining their modes of action, the parasites they target, how they are administered, and their main advantages and disadvantages — all to help you determine the best choice for your dog.

What Is Heartgard Plus?

Heartgard Plus is a monthly chewable that protects dogs from heartworm disease and treats and controls roundworms and hookworms. It contains ivermectin and pyrantel — two active ingredients that kill parasites before they cause serious health issues.

How It Works:

  • Ivermectin kills heartworm larvae in the bloodstream before they mature into adult worms.
  • Pyrantel paralyzes and eliminates intestinal parasites like roundworms and hookworms.

Key Benefits:

  • Tasty beef-flavored chew that most dogs eat like a treat
  • Provides essential protection against deadly heartworms
  • It helps prevent intestinal worm infestations

Dosage Chart of Heartgard Plus Chewable

Pack Colour
Body Weight
Dog Size
Ivermectin Content (mg)
Pyrantel Content (mg)
Product Page
Blue
Up to 25 lbs (11 kg)
Small
68
57
Green
26 to 50 lbs (12-22 kg)
Medium
136
114
Brown
51 to 100 lbs (23-45 kg)
Large
272
227
 
Over 101.0 lbs (46 kg)
Administer the appropriate combination of chewable

What Is Revolution?

Revolution is a topical (spot-on) treatment that offers broad-spectrum protection. It prevents heartworms, fleas, ear mites, sarcoptic mange, and even ticks in some versions, like Revolution Plus (for cats) or Revolution for dogs.

It contains selamectin, which is absorbed through the skin into the bloodstream and affects a wide range of internal and external parasites.

Key Benefits:

  • One solution for heartworms, fleas, and other pests
  • Simple once-a-month topical application
  • Waterproof after 2 hours

Dosage Chart of Revolution For Dogs

Pack Colour
Body Weight
Volume (ml)
Potency (mg/ml)
Total Selamectin (mg)
Product Page
Pink
Up to 5 lbs (2.3 kg)
0.25
60
15
Purple
5.1-10 lbs (2.4-4.5 kg)
0.25
120
30
Brown
10.1-20 lbs (4.6-9 kg)
0.5
120
60
Red
20.1-40 lbs (9.1-18 kg)
1.0
120
120
Teal
40.1-85 lbs (18.1-38.5 kg)
2.0
120
240
Plum
85.1-130 lbs (38.6-59 kg)
3.0
120
360
 

Key Differences Between Heartgard Plus and Revolution

Let’s break down the core differences to make your decision easier.

Feature
Form Chewable tablet Topical (applied to the skin)
Active Ingredients Ivermectin & Pyrantel Selamectin
Heartworm Prevention
Flea Control
Tick Protection (varies by product version)
Intestinal Worms Roundworms & Hookworms
Ear Mites / Mange / Lice
Ease of Administration Tasty chew Spot-on (may need drying time)
Puppy Use 6 weeks and older 6 weeks and older

 

Which One Is Best for Your Dog?

The answer depends on your dog’s needs and where you live. Let’s look at a few scenarios:

✅ Choose Heartgard Plus if:

  • You want strong protection against intestinal worms like roundworms and hookworms.
  • Your dog doesn’t have flea or mite problems, or you’re using a separate flea treatment.
  • Your pet prefers a chewable over topical treatments.

✅ Choose Revolution if:

  • You want all-in-one protection, especially against fleas, mites, and mange.
  • You live in a flea-prone or warmer climate.
  • Your dog has sensitive digestion and may not tolerate oral medications well.

Some pet parents even use Heartgard Plus for heartworm and intestinal worms, and another flea/tick topical for full coverage. However, it's important to check with your veterinarian before using multiple products together.

Safety and Side Effects

Both Heartgard Plus and Revolution are FDA-approved and considered safe for most dogs. However, mild side effects can occur:

Always follow dosage instructions and discuss any reactions with your veterinarian.

Cost Comparison

Cost is another factor to consider:

  • Heartgard Plus is generally more affordable than Revolution, especially if you use it just for heartworms and worms.
  • Revolution is slightly more expensive but laces multiple products, making it cost-effective if your dog needs flea, mite, and worm prevention in one.

Buying in larger packs (6 or 12 months) online often saves money. Both medications can be found at discounted rates from trusted pet pharmacies.

Final Thoughts

There is no one-size-fits-all answer, but here's a quick summary:

Whichever you choose, consistent monthly prevention is key to keeping your dog safe and healthy. Consult your veterinarian to get tailored guidance based on your dog’s lifestyle and potential risk factors.

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Best Selling Combo

Best Selling Combo

Heartgard Nexgard Combo for Dogs Flea, Ticks & Heartworm Treatment

Customer Reviews

Overall rating: 4.8 / 5 from 1134 reviews.

Customer photo review of Custom Duty

Fast shipping great quality and price

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Customer photo review of Revolution Plus For Medium Cats 5.6-11 lbs (2.6-5kg)

Two sweet girlies decided to make our deck their home. Mosquitoes are a big problem where we live and we had to get them protected. This was the best bang for the buck. I’ve ordered from 79Pets several times and while delivery is not fast it is very consistent.

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Customer photo review of Nexgard Combo For Cats 5.5-16.5 lbs (2.5-7.5 kg)

As a retired veterinary technician I was extremely happy to finally see a flea and heartworm medication that actually does tapeworms too!!!!!!! This is a 1st to my knowledge....I live in a tropical climate where fleas never die so this is heaven sent.

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Customer photo review of Stronghold Teal For Dogs 44-88lbs (20-40kg)

Very happy with the price of Stronghold heart worm med for my dog. Seems to be working well.

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Customer photo review of NexGard Chew For Small Dogs 10-24lbs (4-10kg)

I have 3 of these little rascals so Michigan flea/tick season can be financially brutal! Thank you for keeping NexGard so affordable.

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Customer photo review of Nexgard Combo for Cats 5.5-16.5 lbs (2.5-7.5 kg)

After Seresto collars failed to get rid of fleas, I didn't know where to turn. I saw a post on a page I follow (Kentucky Kitty Cats) saying that they use Nexgard Combo for the cats they shelter. I decided to try it and IT WORKS!

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Customer photo review of Revolution Plus For Large Cats 11.1-22lbs (5-10kg)

This is Lexi Marie! She was wondering why mom was so excited for buying flea medicine. I explained to her that we saved $100 and that she would understand some day when she grows up.

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Customer photo review of Revolution Plus For Medium Cats 5.6-11 lbs (2.6-5kg)

Last year, I made a visit to the vet. I told them that Kattie/cat had ear mites. They gave me an ointment costing $80canadian. I used it up and purchased another bottle. $160. total not including the cost of the vet visit. No results. The ear mites have been there for a long time. Canadian vets have control of what is sold in Pet stores and you cannot purchase off the shelf products not recognized by them. I jumped at the chance to purchase your produce with a recommended 100% effectivity. I was willing to try, but was suspicions. After a month there was still a little scratching but after 6 weeks, the mites are gone and the scratching is gone. Thank you very much for this mite solution. I recommend it heartily. Harry P.S. Do not tell the Canadian vets as they will outlaw your product.

Revolution Plus For Medium Cats 5.6-11 lbs (2.6-5kg)

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