I love the nexguard tablets for my dog. He is so allergic to fleas. Without this medication he breaks out pitifully. So thankful I found this at a reasonable price!
NexGard Chewables Purple for Medium Dogs 24-60 lbs (10–25 kg)
Frontline Plus vs. alternatives depends on what your dog or cat needs and how much you’ll pay to keep that protection going. Frontline Plus can be good value if a monthly flea-and-tick spot-on fits your routine and you already have a separate plan for heartworm prevention. A longer-lasting option may suit you better if monthly doses are easy to forget.
What does Frontline Plus cover?
Frontline Plus combines fipronil, which kills adult fleas and ticks, with (S)-methoprene, which interrupts flea egg and larval development. It’s applied to the skin and typically used monthly for flea and tick control. Dog and cat formulas are sold separately. Budget for heartworm or intestinal worm protection separately if your vet recommends it.
Compare spot-ons, chews, and collars
For a fair Frontline Plus vs. alternatives comparison, check that each option covers the parasites your vet recommends. The examples below use U.S. labeling. Check your pack for the species, minimum age, current weight range, and dosing instructions.
|
Option |
What to consider |
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Flea-only spot-on |
Advantage II is a monthly topical option in separate dog and cat formulas. It can make sense when you need flea control alone. If your pet needs tick protection, include that in your budget. |
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A chew can be easier if your dog resists spot-ons. One dose covers fleas and several tick species for 12 weeks. The U.S. label lists eight weeks for Lone Star ticks. |
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Separate dog and cat collars can provide up to eight months of flea and tick control. Check the fit and water-exposure instructions. Frequent swimming can shorten protection for dogs. |
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This monthly spot-on covers fleas and labeled ticks, prevents heartworm disease, and treats ear mites, roundworms, and hookworms. Compare its price with the combined cost of the products your cat would otherwise need. |
How to compare the total cost
When pricing Frontline Plus vs. alternatives, divide the pack price by the number of doses to get the price per dose. Then count how many doses you’ll need over the same period. Include shipping and any separate preventives your vet recommends.
Here’s a 24-week example for a dog in the 44–88 lb (20–40 kg) size range, using 79Pets prices checked November 12, 2026.
|
Product and dosing interval |
Purchase for 24 weeks |
Total (USD) |
|
Frontline Plus for large dogs, monthly |
Two 3-dose packs at $52.95 each |
$105.90 |
|
Bravecto Chews for large dogs, 12 weeks |
Two single chews at $59.95 each |
$119.90 |
|
Bravecto Chews, 8 weeks for Lone Star ticks under the U.S. label |
Three single chews at $59.95 each |
$179.85 |
With these pack sizes, Frontline Plus costs $14.00 less than Bravecto at the 12-week interval and $73.95 less at the 8-week interval. Bravecto requires fewer doses over the same period. Prices are before shipping and discounts. Check the price of the pack size you plan to buy, since multipacks can change the comparison.
A larger pack can reduce the price per dose. Before buying, check whether you’ll use every dose before it expires and whether a growing puppy or kitten may soon need a different pack.
Which option fits your pet?
For dogs, the Frontline Plus vs alternatives decision often comes down to which format you can give reliably. If skin application is a struggle, ask your vet whether a chew suits your dog, especially if your dog has a history of seizures. For cats, start with the coverage your vet recommends. A monthly flea and tick spot-on may be enough when other parasite needs are already covered. If your cat needs several preventives, compare the total cost with a combination product. Ask your vet before switching or combining treatments.
Frequently asked questions
Is Frontline Plus always the cheapest option?
Prices vary by pack size and weight range. When comparing Frontline Plus vs alternatives, use your pet’s exact pack and compare the delivered cost for the same period of protection.
Why am I still seeing fleas after treatment?
New fleas can emerge from carpets or bedding while you’re getting an infestation under control. Vacuum regularly, wash pet bedding, and ask your vet about species-appropriate treatment for every pet in the home. Follow the label schedule and check with your vet before giving an extra dose.
Ready to restock? Compare Frontline Plus pack sizes at 79Pets and choose the formula for your pet’s species and current weight.
